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Ask Dr. Stephan Moll
These questions have been submitted by folks on the mailing list and answered by Dr. Moll, Director of the Thrombophilia Program at the Carolina Cardiovascular Biology Center, Department of Medicine, Division of Hematology-Oncology, UNC Chapel Hill (North Carolina, USA). Why am I doing this?
6. Lovenox®, Fragmin® and other low molecular weight heparins
Last Updated: 2/15/2004
Q1: Are there known side-effects after having been on Lovenox for over one year?
A1: Bleeding and possibly osteoporosis.
Q2: Is it possible to have a clot while on Lovenox, using the appropriate dosage level calculated against body weight?
A2: Yes, it is possible, but uncommon. New blood clots (recurrence of DVT or PE) occur in approximately 2-5 % of patients treated with full dose
LMWH.
Q3: When measuring the effectiveness of Lovenox, does one run a PTT?
A3: No. The PTT is only minimally prolonged by Lovenox and other low molecular weight heparins (= LMWHs) and is therefore not helpful. If one wants
to measure the effectiveness of LMWHs, one needs to obtain an "anti-Xa level" (= "heparin level").
Lovenox belongs to the group of "low molecular weight heparins" (= LMWHs). Several LMWHs are on the market. While they differ a little pharmacologically, clinically they are all more or less equally effective and safe. In the US the following LMWHs are available:
- Lovenox (= Enoxaparin)
- Fragmin (= Dalteparin)
- Innohep® (= Tinzaparin)
Outside the US the following LMWHs are also available:
- Fraxiparin ® (= Nadroparin)
- Clivarine ® (= Reviparin)
- Monoembolex ® (= Certoparin)
The information contained on the this web site is provided for your general information only. I am not a doctor and I do not give medical advice or engage in the practice of medicine. I do not recommend any particular treatment/trial for individuals, and in all cases recommend that you consult your physician or local treatment center before pursuing any course of treatment. It is up to you, as a consumer to find out if these trials posted are something you want to participate in. I just post the information.